Jordan Brown misplaced 6-0 to John Higgins within the first spherical of the Gamers Championship, three days after successful a primary rating match.
Northern Irishman Brown lifted the Welsh Open title on Sunday however was not given an opportunity by Scotland’s Higgins.
The four-time world champion made a century break in every of the primary three frames of a snug win.
Higgins will face Mark Selby within the final eight following his 6-4 victory over Welshman Mark Williams.
Williams led 2-0 and 4-3 within the match however Selby took the ultimate three frames with consecutive breaks of 78, 73 and 64.
Elsewhere on Wednesday, Barry Hawkins superior to the semi-finals with a 6-2 win towards Stuart Bingham.
Hawkins rallied to say 5 unanswered frames after Bingham had taken a 2-1 lead, and can play both Ronnie O’Sullivan or Jack Lisowski for a spot within the ultimate.
Brown, a 750-1 outsider, beat O’Sullivan 9-8 within the Welsh Open ultimate on Sunday to turn into the lowest-ranked winner of a rating occasion since 1983.
However he was closely overwhelmed in his first outing since that victory, as Higgins hit 122, 133 and 121 throughout an emphatic begin to the match in Milton Keynes.
The Scot was on target to turn into the primary participant in historical past to hit 4 opening centuries on two completely different events, having achieved the feat towards O’Sullivan in 2005.
Nevertheless, a nasty place after potting a pink meant his fourth-round break stalled at 57, however he nonetheless went into the interval 4-0 forward.
Brown acquired into the match for the primary time in body 5 however a poor miss on the pink whereas 58-49 up noticed him sacrifice the body, with Higgins take the sixth body comfortably.